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By Andrew D Shaw; et al

ISBN-10: 0824726898

ISBN-13: 9780824726898

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Nature 1979; 280:358–360. 10. Killion JJ. Immunotherapy with tumor subpopulations. II. Therapy of drug-resistant L1210 leukemia and E14 lymphoma. Cancer Immunol Immunother 1979; 5: 21–26. 11. Malkovska V, Sondel PM, Malkovsky. Tumor immunotherapy. Curr Opin Immunol 1989; 1:883–890. 12. Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889; 1:571–573. Killion and Fidler 13. Fidler IJ. A. Clowes memorial award lecture. Cancer Res 1990; 50:6130–6138. 14. Fidler IJ. Experimental orthotopic models of organspecific metastasis by human neoplasms.

Indeed, blood vessels in tumors are different than those found in wound healing and inflamed tissues. The blood flow through tumors can be tortuous and constantly modeled by regions of necrosis, rapid cell division, and presence of infiltrate cells. Receptors for VEGF (KDR in humans, Flt-1 in mice) are expressed specifically by tumor endothelium, as well as by the angiopoietin tyrosine kinase receptor, Tie-2 (37). In addition, receptors for PDGF and EGF are found on tumor endothelial cells (38–40).

Science 1987; 235:305–311. 5. Poste G, Fidler IJ. The pathogenesis of cancer metastasis. Nature 1980; 283:139–146. 6. Heppner G. Tumor heterogeneity. Cancer Res 1984; 44: 2259–2265. 7. Nicolson GL. Generation of phenotypic diversity and progression in metastatic tumors. Cancer Metastasis Rev 1984; 3:25–42. 8. Killion JJ, Kollmorgen GM. Isolation of immunogenic tumor cells by cell-affinity chromatography. Nature 1976; 259:674–676. 9. Kerbel RS. Implications of immunological heterogeneity in tumors.

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Acute care of the cancer patient by Andrew D Shaw; et al


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