Download e-book for kindle: A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

ISBN-10: 1493920944

ISBN-13: 9781493920945

ISBN-10: 1493920952

ISBN-13: 9781493920952

The blood method is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood involves circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments consequence from a highly-ordered strategy, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells provide upward thrust to a number of lineages of hugely really good cells. Highly-productive and regularly regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A structures Biology method of Blood is split into 3 major sections: simple elements, physiological tactics, and scientific purposes. utilizing blood as a window, you can research health and wellbeing and affliction via this designated device field with reactive organic fluids that mirrors the existing hemodynamics of the vessel partitions and many of the blood phone forms. Many blood illnesses, infrequent and customary can and feature been exploited utilizing platforms biology methods with winning effects and accordingly perfect versions for platforms medication. extra importantly, hematopoiesis bargains the most effective studied platforms with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are each day stimulated by means of the main mature and understood regulatory networks.

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Fliedner TM, BondVP, Cronkite EP. Structural, cytologic and autoradiographic (H3-thymidine) changes in the bone marrow following total body irradiation. Am J Pathol. 1961;38:599–623. 19. Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, et al. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007;109(6):2365–72. 20. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006;6(2):93–106.

Handbook of stem cells. Burlington: Elsevier; 2004. 13. Loeffler M, Roeder I. Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models—a conceptual approach. Cells Tissues Organs. 2002;171(1):8–26. 14. Potten CS, Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development. 1990;110(4):1001–20. 15. Yilmaz OH, Kiel MJ, Morrison SJ. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.

1961;38:599–623. 19. Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, et al. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007;109(6):2365–72. 20. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006;6(2):93–106. 21. Arai F, Suda T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci. 2007;1106:41–53. 22. Doan PL, Chute JP.

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A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard


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